Hillel Yaffe Medical Center – Research Activity

symbol of Hillel Yaffe Medical Center

The main research activity in Hillel Yaffe MC by several of the leading departments:

Surgery – Research is an integral component of the department’s academic mission.  Physicians and nurses are involved both in basic science and clinical research at the local, national and international level.  In 2013, a laboratory dedicated to basic surgical research was inaugurated.  Past and present research led by our staff include: new monitoring techniques in severely injured patients; controlled and uncontrolled bleeding in head trauma in a rat model; serologic proteomics in solid tumors; impact of imaging on treatment of acute surgery cases.
Orthopedic B – The main research activity focuses on bench to bedside studies of novel expandable intramedullary trauma implants and spine implants made of carbon – fiber polyaryl-ether-ether-ketone (cf-peek) composite, along with numerous clinical descriptive studies.
Gastroenterology – Recent studies cover the fields of new drugs for the treatment of inflammatory bowel diseases and hepatitis C, new biliary stents for the treatment of pancreatic – biliary malignancies, video – capsule examination efficacy among anemic patients and the yield of colonoscopy surveillance of post-surgery colon cancer patients.
Pathology – Most research is related to Gastrointestinal Pathology and immunohistochemistry. Lately, it was concentrated in a recently described colorectal mucosal polyp named “colorectal mucosal perineurioma”  including analysis of its histologic features, histological variants, immunohistochemical and molecular characteristics and clinical-endoscopic-pathological correlations.
Nursing – Research is concentrated mostly in cardiology, intensive care nursing, treatment of organ donors and trauma injuries . The research focuses on patients coping with acute illness event, informational needs and uncertainty of critically ill patient’s families, medical staff experience in treatment of organ donor and head trauma patients transfer criteria to higher level trauma centers.
Obstetrics, Gynecology and Reproductive Endocrinology & Infertility – The research includies basic science, clinical and data-base studies. Basic science research (performed mainly in our own laboratories) includes: fetal brain damage with maternal insults: protection by MgSO4; an infection based model of neurodevelopmental damage; the role of immature myeloid cells and dendritic cells in angiogenesis and their effect on placenta and pregnancy, embryonic implantation and tumor /endometriosis progression. Clinical research is mainly in the areas of parturition, fetal behavior and prenatal diagnosis and evaluation of various IVF protocols.
Imaging – The department is engaged in different research projects, some in close cooperation with other departments, including correlation between clinical and imaging findings, comparison between different modalities and follow-up of incidental findings.
Neurology – Research topics include head and neck pain biomechanics, imaging, propriceptive sensory processing, neuromotor control of movement utilizing surface EMG and development of computerized 3-dimensional. neck mobilization novel therapy, and; acute stroke optimization of “door to needle” TPA treatment, patent foramen ovale as a risk factor utilizing combined TCD and TEE; peripheral nerve disorders in Thromboangitis Obliterans.
Internal Medicine D – Multicenter evaluation of various novel therapies in Rheumatoid arthritis , including Rituximab, Actemra (Tocilizumab), especially in patients with an inadequate response to disease-modifying antirheumatic drugs. In addition to two recent studies: Effect of medical therapy on segmental myocardial function, more specifically on longitudinal contractility and effect of high dose corticosteroids on myocardial contractility.
ENT – Research includes clinical efficacy in chronic rhinitis with or without nasal polyps and/or chronic sinusitis of topical nasal Pomegranate fruit extract (PFE) (Punica Granatum); influence of Bariatric Surgery on Patients with Obstructive Sleep Apnea (OSA); applications of nanotechnology and chemical sensors (electronic nose) for detection of chronic sinusitis subtypes by respiratory sample.
Ophthalmology – The department runs a wide variety of laboratory research in collaboration with the technion and the faculty of medicine, mainly stem cells research and studies on the antimicrobial activity of peptidomimetics in mouse keratitis model. In addition, there are a wide variety of ongoing clinical studies, such as toxic anterior segment syndrome, retinal studies based on optical coherence tomography and glaucoma studies including new surgical technique.
Neonatology – Research includes clinical evaluation of Paracetamol treatment of patent ductus arteriosus in preterm infants; compliance in a well-baby nursery; follow-up of newborns with prenatal diagnosis of isolated hydronephrosis; 5 years experience of Satisfaction questionnaire in a neonatal intensive care unit.
Anesthesiology – Reseach activity is mainly clinical comparing various block approaches like supraclavicular, infraclavicular and axillary approach of ultrasound-guided brachial plexus block; efficacy of a single shot femoral nerve block alone for  pain relief after total knee arthroplasty versus addition of sciatic, obturator and lateral femoral cutaneous nerve blocks; ultrasound – guided transverses abdominis plane versus ilioinguinal/iliohypogastric after open inguinal herniorrhaphy; perineural and systemic adjuvant effect of dexamethasone for interscalene plexus block; preemptive epidural block protection of killer cells activity in colorectal surgery.
Psychiatry –The main research includes childhood onset schizophrenia resistant to antipsychotic treatment; Metabolic syndrome in children with antipsychotic treatment; Platelet-associated  autoantibodies in adolescent and child psychiatry.
Pediatrics – The main research includes pulmonary hypertension and heart function; epidemiology of infectious diseases pre and post vaccination; vitamin D receptor polymorphism and impact dairy consumption on clinical status and body measurements; breastfeeding duration association with metabolic syndrome among obese children; various aspects including host-response based diagnostics of viral and bacterial coinfections; diagnostic marke of  rs infection in pediatric febrile patients.
Pediatric Neurology and Child Development – Research topics include neurogenetic diseas, mental retardation, autism, child developmental disorder, epilepsy, attention deficit disorder, learning disabilities.
Vascular Surgery – The research includes clinical evaluation of vertebral artery ischemia and revascularization and novel stent therapy of abdominal aortic aneurysm.
Oncology – The research activities include clinical, laboratory and social aspects of oncology patient’s care; multicenter clinical trials of modern chemotherapy and biological drugs: genetic and molecular biology and epidemiology research of cancer in collaboration with the National Cancer Control Center and Department of Community Medicine and Epidemiology ( Carmel MC); molecular biology differences, chemotherapy dependence, and genetic polymorphism of colorectal cancer; several studies evaluating different aspects of oncology care of colon carcinoma are pending collaboration with Rambam Oncology Institute.
Cardiology – A large research unit that is involved in numerous industry sponsored trials as well as local non-funded studies; a large registry of our acute coronary syndrome (ACS) patients; participate in large multicenter registries: national – cardiac implanted electronic devices; ACSIS (Israeli ACS) and European registries of heart failure, heart problems in pregnancy and peripartum cardiomyopathy. Our local research includes bio-impedance in acute and chronic heart failure; clinical evaluation of coronary slow flow; early thrombolysis versus primary PCI; BNP in hospitalized patients; echocardiographic LV strain; the role of the left atrium; the impact of medications and devices on cardiac strain and function; development of enhanced imaging of coronary angiography and intervention.

Academic Appointments –  Bruce Rappaport Medical school, Technion

  1. Prof Michael Krausz (Surgery) – Professor
  2. Prof Hallak Mordechai (Obstetrics-Gynecology) – Associate Professor
  3. Prof Oren Meir (Management) – Associate Clinical Professor
  4. Prof Alfici Ricardo (Surgery) – Associate Clinical Professor
  5. Prof Chouraqui Pierre (Nuclear Medicine & Cardiology) – Associate Clinical Professor
  6. Prof Groisman Gabriel (Pathology) – Associate Clinical Professor
  7. Prof Meisel Simcha (Cardiology) – Associate Clinical Professor
  8. Prof Shotan Avraham (Cardiology) – Associate Clinical Professor
  9. Prof Sternberg Ehud (Surgery) – Associate Clinical Professor
  10. Prof Fainaru Ofer (Obstetrics-Gynecology) – Assistant Professor
  11. Prof Ashkenazi Itamar (Surgery) – Assistant Clinical Professor
  12. Prof Abd-El-Rauf Zeina (Imaging) – Assistant Clinical Professor
  13. Prof Blondheim David (Cardiology) – Assistant Clinical Professor
  14. Prof Blumen Sergiu (Neurology) – Assistant Clinical Professor
  15. Prof Braverman Itzhak (ENT) – Assistant Clinical Professor
  16. Prof Ellenbogen Adrian (Obstetrics-Gynecology) – Assistant Clinical Professor
  17. Prof Frimerman Aharon (Cardiology) – Assistant Clinical Professor
  18. Prof Folman Yoram (Orthopedics) – Assistant Clinical Professor
  19. Prof Kopelman Yael (Gastroenterology) – Assistant Clinical Professor
  20. Prof Mahagna Muhamad (Pediatrics) – Assistant Clinical Professor
  21. Prof Shochat Michael (Cardiology) – Assistant Clinical Professor
  22. Prof Shrim Alon (Obstetrics-Gynecology) – Assistant Clinical Professor
  23. Prof Carasso Rafael (Neurology) – Senior Lecturer of the practice
  24. Dr Abu-Much Seif (Internal Medicine) – Senior Lecturer of the practice
  25. Dr Tiossianu Beatrice (Ophthalmology) – Senior Lecturer of the practice
  26. Dr Yarchovsky Yaacov (Internal Medicine) – Senior Lecturer of the practice
  27. Dr Feiner Benjamin (Obstetrics-Gynecology) – Clinical Lecturer
  28. Dr Feldman Michael (Neonatology) – Clinical Lecturer
  29. Dr Kassem Eias (Pediatrics) – Clinical Lecturer
  30. Dr Klein Adi (Pediatrics) – Clinical Lecturer
  31. Dr Nachtigal Alicia (Imaging) – Clinical Lecturer
  32. Dr Anderman Shmuel (Obstetrics-Gynecology) – Lecturer of the practice
  33. Dr Erlich Nahum (Urology) – Lecturer of the practice
  34. Dr Nadir Erez (Neonatology) – Lecturer of the practice
  35. Dr Sharon Avishalom (Obstetrics-Gynecology) – Lecturer of the practice
  36. Avshovich Nina (Internal Medicine) – Clinical instructor
  37. Dr Erlich Nachum (Urology) – Clinical instructor
  38. Dr Istomin Valery (Internal Medicine) – Clinical instructor
  39. Dr Amit Hochberg (Neonatology) – Clinical instructor, fellow
  40. Dr Gal Oren (gastroenterology) – Clinical instructor
  41. Dr Kirshon Mark (Surgery) – Clinical instructor
  42. Dr Nir Vered (Pediatrics) – Clinical instructor, fellow
  43. Dr Shabtai Sergio (Neurology) – Clinical instructor
  44. Dr Yakubov Renata (Pediatrics) – Clinical instructor
  45. Dr Younes Said (Internal Medicine) – Clinical instructor