Bnei Zion Medical Center – Current Research Topics

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Urology department
Urology department research fields include new markers for bladder cancer. Hyperthermia vs. BCG for the prevention of bladder cancer recurrence. Diphtheria toxin for the prevention of bladder cancer recurrence. Nephron sparing surgery for complex renal tumors impact on renal function and oncological outcome.  Models to predict bladder cancer recurrence and progression.  Allium stent –a newly designed stent for chronic urethral strictures. The research staff include: Prof. Ofer Nativ, director of the urology department. Clinical Associate Prof. Sarel Halachmi and  Clinical Assistant Prof. Boaz Moshkovitz.

The Hannah Khoushy Child Development Center
The Hannah Khoushy Child Development Center research fields include Attention Deficit Hyperactivity Disorder, Heart Rate Variability and neurodevelopmental / environmental factors and Autism – diagnostic procedure and treatment. The research is done by the director of the center, Clinical associate Prof. Tirosh Emanuel.

Internal Medicine A
Internal Medicine A department research is focusing on the involvement of cytokines in the pathogenesis of various diseases and clinical and basic research in rheumatology. The staff include: Associate Prof. Odeh Majed and Clinical Assistant Prof. Gleb Slobodin

Department of Otolaryngology Head and Neck surgery
The Department of Otolaryngology Head and Neck surgery is involved in both basic and clinical research. The Ear ad Hearing research team (Prof. Luntz*, Dr. Shpak, Dr. Yehudai*, Dana Egra) cochlear implantation research including hearing preservation in cochlear implantation, single sided deafness, and bimodal hearing (cochlea implantation in one ear and a hearing aid in the contra-lateral ear), epidemiology of vertigo, epidemiology of tinnitus and outcomes of trans-cutaneous bone anchored hearing aids.The acute mastoiditis team (Prof. Luntz*, Dr. Koren) is focused on the role of imaging for early diagnosis of intra-cranial complications in acute mastoiditis (a meta-analysis). The sleep apnea team (Dr. Brodsky* in cooperation with Prof. Olivan) is focused on the influence of electrical stimulation of Nerve XII on the resistance of the upper airways and the severity of sleep apnea.The nose and sinuses team (Dr. Shihada*, Dr. Wolfovich*) is focused on the HRCT anatomy of the nasal sinuses. The department cooperates with the department of mechanical Engineering at the Technion (Professor Moshe Shoham), Department of Mathematics at the Technion (Prof. Kobi Rubinstein), School of Education, Department of Communication Disorders, Tel Aviv University (Prof Most), and the Department of Communication Sciences and Disorders, University of Haifa (Prof. Attias).

Pediatrics department
Members of the pediatric division of Bnai Zion Medical center engage in prevention- and treatment-oriented research activities across a range of pediatric sub-disciplines.  With respect to prevention, the division’s physicians use a variety of epidemiological approaches to enhance our understanding of the nature and etiology of adolescent risk behaviors and emotional disorders such as eating disorders and non-suicidal self-harm (Dr kerem Nogah), infectious diseases such as pertussis and various STDs (Clinical associate prof. Srugo Isaac), respiratory and coronary disorders (e.g., bronchopulmonary dysplasia) and pediatric and adolescent headache.  Treatment-oriented research activities include studies examining both diagnostic and intervention efficacy.  For example, several division members investigate factors affecting the relative utility of alternative methods of diagnosing Bordetella pertussis (Dr Bamberger Ellen) . In terms of intervention research, on-going research activities include studies examining carotid intimal medial thickness and endothelial function in children with hyperlipidemia before and following intervention (Dr Liat Yani), non-invasive methods for CO2 monitoring and ventilation in newborn infants, and new approaches for more effectively treating pediatric headache (Dr Genizi Jacob).

Simon Winter Institute for Human Genetics
The main research area of Clinical Associate Prof. Zvi Borochowitz the director of the institute include; the elucidation of the mechanism of morphogenesis and dysmorphology of congenital malformations, the estimation of prevalence of malformations and syndromes in the general population. In addition, Being the Nnational Center for Diagnosis and Treatment of Bone Dysplasia (Osteochondrodystrophies), research is conducted in this area, especially on genotype / phenotype relations of these syndromes. Recent research projects include; Genotype /phenotype of a distinct Obesity new syndrome, related to the discovery of a novel Obesity gene -MO-1.Genotyping /phenotyping (metabolomics and proteomics) of a novel obesity knockout mice and Genotype/phenotype of several novel hereditary new distinct syndromes.

Cardiology Department
The Department of Cardiology is involved in research in wide spectrum of subjects in cardiology including Acute Coronary Syndromes, CHF, prevention and new technologies as well as involvement in multiple drug trials. Associate Prof Uri Rosenschein is involved in innovative new technology developments including new devices in interventional cardiology, collaboration with CS and EE faculties at the Technion on Smart Phone based patient monitoring systems. Micro biome involvement in heart attacks in collaboration with bar ilan university. Clinical associate Prof Goldhamer research is in cardiac rehabilitation and prevention of cardiac diseases. Dr Dobrezky is investigating the involvement of diabetes in ACS patients. Dr Samania is initiating a study on the modolation of immune system in CHF patients treated with vagal stimulation. Prof Sharif is studying coronary flow in various patient populations using unique non invasive method.

Pediatric Surgery
Associate Professor Sukhotnik Igor main research area include animal models of Short bowel syndrome, Intestinal ischemia-reperfusion and  Chemotherapy-induced intestinal mucositis. He is also conducting basic research in the area of Testicular torsion and germ cell apoptosis.

Division of Allergy and Clinical Immunology
In the division of Allergy and Clinical Immunology we see and treat patients suffering from a wide range of allergies and autoimmune diseases. We are a reference laboratory in which wide panel of immunology tests are performed, namely specific autoantibodies following which we are able to better define and classify autoimmune diseases. We run active clinical and basic research in which all the staff is involved. We also guide students for Master and PhD degrees. Of the many research projects we are running the following: Allergy: a. Milk allergy. b. hyperactivity in atopic children. c. inflammatory mechanisms in celiac disease.Autoimmune diseases: a. B regulatory cells. b. The role of semaphorins in autoimmune diseases. c. Immune regulatory mechanisms in HCV infection. Our research staff includes; Associate prof. Toubi E lias, Clinical associate prof. Kessel Aharon, clinical assistant prof. Vadasz Zahava.

The Department of Neonatology
The Department of Neonatology has special interest in new mode of ventilation preterm infant especially noninvasive ventilation, prevention and treatment of bronchopulmonary dysplasia, Novel methods for non-invasive CO2 monitoring and Late preterm infants. The staff team include: Clinical associate prof. Bader David, Clinical associate prof. Kugelman Amir and Clinical assistant prof. Riskin Arik.

The Infectious Diseases unit
The Infectious Diseases unit along with the Infection control unit is conducting research on Travel medicine, Infection control issues and general ID (currently endocarditis) by clinical associate prof. potasman Israel.