Hershko Avram - Research Professor

avram hershko

Alma Mater

1965 M. D.-The Hebrew University-Hadassah Medical School, Jerusalem, Israel. (Cum Laude ).

1969 Ph. D.-The Hebrew University-Hadassah Medical School, Jerusalem, Israel. (Summa Cum Laude ).


Journal articles

Click here for a list of available publications in PubMed.

Items 1 –  69

1: Moshe Y, Boulaire J, Pagano M, Hershko A
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.
Proc Natl Acad Sci U S A 01/01/2004; 101: 7937 – 42


2: Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.
Nature 01/11/2003; 426: 87 – 91


3: Bornstein G, Bloom J, Sitry-Shevah D, Nakayama K, Pagano M, Hershko A
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase.
J Biol Chem 01/01/2003; 278: 25752 – 7


4: Donzelli M, Squatrito M, Ganoth D, Hershko A, Pagano M, Draetta GF
Dual mode of degradation of Cdc25 A phosphatase.
EMBO J 01/09/2002; 21: 4875 – 84


5: Golan A, Yudkovsky Y, Hershko A
The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk.
J Biol Chem 01/01/2002; 277: 15552 – 7


6: Sitry D, Seeliger MA, Ko TK, Ganoth D, Breward SE, Itzhaki LS, Pagano M, Hershko A
Three different binding sites of Cks1 are required for p27-ubiquitin ligation.
J Biol Chem 01/01/2002; 277: 42233 – 40


7: Hershko D, Bornstein G, Ben-Izhak O, Carrano A, Pagano M, Krausz MM, Hershko A
Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas.
Cancer 01/05/2001; 91: 1745 – 51


8: Ganoth D, Bornstein G, Ko TK, Larsen B, Tyers M, Pagano M, Hershko A
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27.
Nat Cell Biol 01/03/2001; 3: 321 – 4


9: Yudkovsky Y, Shteinberg M, Listovsky T, Brandeis M, Hershko A
Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint.
Biochem Biophys Res Commun 01/05/2000; 271: 299 – 304


10: Hershko A, Jabotinsky K, Mager J
Studies on red cell nucleoside triphosphate pyrophosphohydrolases.
Isr J Med Sci 01/01/2000; 5: 991 – 7


11: Hershko A, Hershko C, Mager J
Increased formation of 5-phosphoriboxyl-1-pyrophosphate in red blood cells of some gouty patients.
Isr J Med Sci 01/01/2000; 4: 939 – 44


12: Razin A, Hershko A, Glaser G, Mager J
The oxidant effect of isouramil on red cell glutathione and its synergistic enhancement by ascorbic acid or 3,4-dihydroxyphenylalanine. Possible relation to the pathogenesis of favism.
Isr J Med Sci 01/01/2000; 4: 852 – 7


13: Carrano AC, Eytan E, Hershko A, Pagano M
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.
Nat Cell Biol 01/08/1999; 1: 193 – 9


14: Shteinberg M, Protopopov Y, Listovsky T, Brandeis M, Hershko A
Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20.
Biochem Biophys Res Commun 01/06/1999; 260: 193 – 8


15: Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A, Pagano M
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.
Genes Dev 01/05/1999; 13: 1181 – 9


16: Shteinberg M, Hershko A
Role of Suc1 in the activation of the cyclosome by protein kinase Cdk1/cyclin B.
Biochem Biophys Res Commun 01/04/1999; 257: 12 – 8


17: Sudakin V, Shteinberg M, Ganoth D, Hershko J, Hershko A
Binding of activated cyclosome to p13(suc1). Use for affinity purification.
J Biol Chem 01/07/1997; 272: 18051 – 9


18: Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV
Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase.
Proc Natl Acad Sci U S A 01/03/1997; 94: 2362 – 7


19: Aristarkhov A, Eytan E, Moghe A, Admon A, Hershko A, Ruderman JV
E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins.
Proc Natl Acad Sci U S A 01/04/1996; 93: 4294 – 9


20: Lahav-Baratz S, Sudakin V, Ruderman JV, Hershko A
Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.
Proc Natl Acad Sci U S A 01/09/1995; 92: 9303 – 7


21: Sudakin V, Ganoth D, Dahan A, Heller H, Hershko J, Luca FC, Ruderman JV, Hershko A
The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.
Mol Biol Cell 01/02/1995; 6: 185 – 97


22: Hershko A, Ganoth D, Sudakin V, Dahan A, Cohen LH, Luca FC, Ruderman JV, Eytan E
Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.
J Biol Chem 01/02/1994; 269: 4940 – 6


23: Eytan E, Armon T, Heller H, Beck S, Hershko A
Ubiquitin C-terminal hydrolase activity associated with the 26 S protease complex.
J Biol Chem 01/03/1993; 268: 4668 – 74


24: Hadari T, Warms JV, Rose IA, Hershko A
A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation.
J Biol Chem 01/01/1992; 267: 719 – 27


25: Hershko A, Ganoth D, Pehrson J, Palazzo RE, Cohen LH
Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.
J Biol Chem 01/09/1991; 266: 16376 – 9


26: Armon T, Ganoth D, Hershko A
Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity.
J Biol Chem 01/12/1990; 265: 20723 – 6


27: Heller H, Hershko A
A ubiquitin-protein ligase specific for type III protein substrates.
J Biol Chem 01/04/1990; 265: 6532 – 5


28: Reiss Y, Hershko A
Affinity purification of ubiquitin-protein ligase on immobilized protein substrates. Evidence for the existence of separate NH2-terminal binding sites on a single enzyme.
J Biol Chem 01/03/1990; 265: 3685 – 90


29: Eytan E, Ganoth D, Armon T, Hershko A
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.
Proc Natl Acad Sci U S A 01/10/1989; 86: 7751 – 5


30: Reiss Y, Heller H, Hershko A
Binding sites of ubiquitin-protein ligase. Binding of ubiquitin-protein conjugates and of ubiquitin-carrier protein.
J Biol Chem 01/06/1989; 264: 10378 – 83


31: Ganoth D, Leshinsky E, Eytan E, Hershko A
A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation.
J Biol Chem 01/09/1988; 263: 12412 – 9


32: Ciechanover A, Ferber S, Ganoth D, Elias S, Hershko A, Arfin S
Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway.
J Biol Chem 01/08/1988; 263: 11155 – 67


33: Reiss Y, Kaim D, Hershko A
Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites.
J Biol Chem 01/02/1988; 263: 2693 – 8


34: Raviv O, Heller H, Hershko A
Alterations in components of the ubiquitin-protein ligase system following maturation of reticulocytes to erythrocytes.
Biochem Biophys Res Commun 01/06/1987; 145: 658 – 65


35: Hershko A, Rose IA
Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.
Proc Natl Acad Sci U S A 01/04/1987; 84: 1829 – 33


36: Hershko A, Heller H, Eytan E, Reiss Y
The protein substrate binding site of the ubiquitin-protein ligase system.
J Biol Chem 01/09/1986; 261: 11992 – 9


37: Hershko A, Heller H
Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates.
Biochem Biophys Res Commun 01/05/1985; 128: 1079 – 86


38: Hershko A, Heller H, Eytan E, Kaklij G, Rose IA
Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown.
Proc Natl Acad Sci U S A 01/11/1984; 81: 7021 – 5


39: Eytan E, Hershko A
Relevance of protease ,”,inhibitor,”, to the ATP-ubiquitin proteolytic system.
Biochem Biophys Res Commun 01/07/1984; 122: 116 – 23


40: Hershko A, Leshinsky E, Ganoth D, Heller H
ATP-dependent degradation of ubiquitin-protein conjugates.
Proc Natl Acad Sci U S A 01/03/1984; 81: 1619 – 23


41: Hershko A, Heller H, Elias S, Ciechanover A
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.
J Biol Chem 01/07/1983; 258: 8206 – 14


42: Hershko A, Eytan E, Ciechanover A, Haas AL
Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins.
J Biol Chem 01/12/1982; 257: 13964 – 70


43: Haas AL, Warms JV, Hershko A, Rose IA
Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation.
J Biol Chem 01/03/1982; 257: 2543 – 8


44: Ciechanover A, Elias S, Heller H, Hershko A
“,Covalent affinity,”, purification of ubiquitin-activating enzyme.
J Biol Chem 01/03/1982; 257: 2537 – 42


45: Hershko A, Ciechanover A, Rose IA
Identification of the active amino acid residue of the polypeptide of ATP-dependent protein breakdown.
J Biol Chem 01/02/1981; 256: 1525 – 8


46: Ciechanover A, Heller H, Katz-Etzion R, Hershko A
Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system.
Proc Natl Acad Sci U S A 01/02/1981; 78: 761 – 5


47: Ciechanover A, Elias S, Heller H, Ferber S, Hershko A
Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes.
J Biol Chem 01/08/1980; 255: 7525 – 8


48: Hershko A, Ciechanover A, Heller H, Haas AL, Rose IA
Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.
Proc Natl Acad Sci U S A 01/04/1980; 77: 1783 – 6


49: Ciechanover A, Heller H, Elias S, Haas AL, Hershko A
ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation.
Proc Natl Acad Sci U S A 01/03/1980; 77: 1365 – 8


50: Rose IA, Warms JV, Hershko A
A high molecular weight protease in liver cytosol.
J Biol Chem 01/09/1979; 254: 8135 – 8


51: Hershko A, Ciechanover A, Rose IA
Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP.
Proc Natl Acad Sci U S A 01/07/1979; 76: 3107 – 10


52: Ciehanover A, Hod Y, Hershko A
A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes.
Biochem Biophys Res Commun 01/04/1978; 81: 1100 – 5


53: Kaftory A, Hershko A, Fry M
Protein turnover in senescent cultured chick embryo fibroblasts.
J Cell Physiol 01/02/1978; 94: 147 – 60


54: Aviram M, Hershko A
Interconversion of multiple forms of tyrosine aminotransferase in vitro and in vivo in cultured hepatoma cells.
Biochim Biophys Acta 01/06/1977; 498: 83 – 90


55: Ciechanover A, Hershko A
Early effects of serum on phospholipid metabolism in untransformed and oncogenic virus-transformed cultured fibroblasts.
Biochem Biophys Res Commun 01/11/1976; 73: 85 – 91


56: Hod Y, Hershko A
Relationship of the pool of intracellular valine to protein synthesis and degradation in cultured cells.
J Biol Chem 01/07/1976; 251: 4458 – 7


57: Epstein D, Elias-Bishko S, Hershko A
Requirement for protein synthesis in the regulation of protein breakdown in cultured hepatoma cells.
Biochemistry 01/11/1975; 14: 5199 – 204


58: Aviram M, Hershko A
Influence of ATP depletion on the degradation of rapidly labeled RNA in cultured hepatoma cells.
Biochem Biophys Res Commun 01/08/1975; 65: 1303 – 10


59: Rafaeli-Eshkol D, Epstein D, Hershko A
Roles of protein synthesis and tRNA aminoacylation in the regulation of intracellular protein breakdown in E. coli.
Biochem Biophys Res Commun 01/12/1974; 61: 899 – 905


60: Rafaeli-Eshkol D, Hershko A
Regulation of intracellular protein breakdown in stringent and relaxed strains of E. coli,.
Cell 01/05/1974; 2: 31 – 5


61: Shechter Y, Rafaeli-Eshkol D, Hershko A
Influence of protease inhibitors and energy metabolism on intracellular protein breakdown in starving Escherichia coli.
Biochem Biophys Res Commun 01/10/1973; 54: 1518 – 24


62: Mamont P, Hershko A, Kram R, Schacter L, Lust J, Tomkins GM
The pleiotypic response in mammalian cells: search for an intracellular mediator.
Biochem Biophys Res Commun 01/09/1972; 48: 1378 – 84


63: Hershko A, Mamont P, Shields R, Tomkins GM
“,Pleiotypic response,”,.
Nat New Biol 01/08/1971; 232: 206 – 11


64: Hershko A, Tomkins GM
Studies on the degradation of tyrosine aminotransferase in hepatoma cells in culture. Influence of the composition of the medium and adenosine triphosphate dependence.
J Biol Chem 01/02/1971; 246: 710 – 4


65: Hershko A, Razin A, Mager J
Regulation of the synthesis of 5-phosphoribosyl-I-pyrophosphate in intact red blood cells and in cell-free preparations.
Biochim Biophys Acta 01/06/1969; 184: 64 – 76


66: Hershko A, Razin A, Shoshani T, Mager J
Turnover of purine nucleotides in rabbit erythrocytes. II. Studies in vitro.
Biochim Biophys Acta 01/11/1967; 149: 59 – 73


67: Mager J, Hershko A, Zeitlin-Beck R, Shoshani T, Razin A
Turnover of purine nucleotides in rabbit erythrocytes. I. Studies in vivo.
Biochim Biophys Acta 01/11/1967; 149: 50 – 8


68: HERSHKO A, WIND E, RAZIN A, MAGER J
Conversion of guanine to hypoxanthine in mammalian red blood cells.
Biochim Biophys Acta 01/06/1963; 71: 609 – 20


69: HERSHKO A, AMOZ S, MAGER J
Effect of polyamines and divalent metals on in vitro incorporation of amino acids into ribonucleoprotein particles.
Biochem Biophys Res Commun 01/05/1961; 5: 46 – 51