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  Home   >   Phone Book   >   Preclinical   >   Department of Anatomy and Cell Biology   >   Academic Staff
 Department of Anatomy and Cell Biology    
Professor Karl Skorecki
Location: Rambam Health Care Campus
Tel: 972-4-854-3250
Fax: 972-4-854-2333
Email: skorecki@tx.technion.ac.il
Website: http://md.technion.ac.il/lecturers/lecturer_desc.asp?lecturerID=10&departmentID=33&contentCatID=13
 Main Research Area

Professor Skorecki’s research group focuses on the regulation of specific genes, which are restricted in expression to specific differentiated cell types in the kidney, in normal and disease states. These genes encode channels and transporters, which govern movement and balance of sodium, potassium, chloride, electrolytes and water in the kidney. In addition, our laboratory is studying epigenetic effects related to telomere regulation and allelic inactivation in hereditary disease and cancer.

 

 Research projects
1.  The Molecular Medicine laboratory that Prof. Skorecki directs, together with Dr. Sara Selig and Dr. Maty Tzukerman, conducts research in varied areas of human molecular genetics and biology. These range from large-scale population genetics projects to the use of the human embryonic stem cells in cancer research. We have recently been engaged in research projects to address the following questions, which exemplify the focus and scope of our work:
  • What are the roles and mechanisms of observed perturbations in the separation of chromosome ends (telomeres) in the replicative arrest and genomic instability associated with aging in health and disease?
  • How are the "immortality enzyme", telomerase, and cell cycle cycle regulators, modulated during human embryonic stem cell differentiation?
  • Can human embryonic stem cells be used to develop a novel experimental platform for studying the stromal reaction and influence of the microenvironment on tumorigenesis responses and for pre-clinical testing of anti-cancer therapies?
  • How does large-scale analysis of DNA sequence variation at the mtDNA and Y-chromosome loci influence our understanding of population history and impact upon patterns of genetic disease in populations and communities of the Near East?
  • Can the genetic analysis of rare disease in specific kindreds and families in northern Israel shed light on mechanisms of more common disease?
  • How can population admixture be used to facilitate the mapping of genetic loci contributing to enhanced susceptibility to common diseases?
  • Can the principles of population genetics be applied to individual cells to promote our understanding of development, differentiation and tumorigenesis?

These multidisciplinary research projects involve a dedicated research team and extensive intra- and inter-institutional collaboration with other centers in Israel and around the world.

 

2. 

Quantitive in situ SA Beta Gal (QBGAL Ver 1.0)

3.  Matlab application for TRF Blot analysis
4.  Cheek Swab DNA Sampling
5. 

Preliminary Report: Missense mutations in the APOL gene family are associated with end stage kidney disease risk previously attributed to the MYH9 gene (June 2010).

Shay Tzur, Saharon Rosset, Revital Shemer, Guennady Yudkovsky, Sara Selig, Ayele Tarekegn, Endashaw Bekele, Neil Bradman, Walter G Wasser, Doron M Behar, Karl Skorecki

 Teaching activities
  • Interactive Course in Nephrology Year IV
  • Clinical elective rotation in Nephrology at Rambam
 Journal articles
   Click here for a list of available publications in PubMed.
 Chapters and reviews in books and proceedings
Skorecki K, Mandel H
Mitochondrial DNA and Heritable Traits and Diseases
Harrison’s Principles of Internal Medicine, 17th ed 2008
Bargman J, Skorecki K
Chronic Kidney Disease, chapter 271
Harrison's Principle's of International Medicine, 17th Edition 2007
Skorecki K, Ausiello D
Disorders of Sodium and Water Homeostasis, Chapter 117
Cecil Textbook of Medicine, 23rd Edition 2007
Skorecki K, Galun E
Cell and Gene Therapy Chapter 41
Cecil Textbook of Medicine, 23rd Edition 2007
Skorecki K, Winaver Y, Abassi Z
Extracellular Fluid Volume and Edema Formation, chapter 12 in Brenner and Rector
The Kidney, 8th Edition 2007
Zelikovics I, Skorecki K, Magen D
Stem Cells in Renal Biology and Medicine, chapter 69 in Brenner and Rector
The Kidney. 8th Edition 2007
Skorecki K
Genetic Ancestry, Jewish
Encyclopedia Judaica, 2nd Edition 2006
 Graduate students
Liran Shlush
Studies towards Ph.D.
Shiran Yechezkel
Studies towards Ph.D.
Effects of Hypomethylation of Subtelomeric Repeats on Telomeric Function in Human Cells.
Liron Yahud
Studies towards Ph.D. Email: liron.yahud@gmail.com
Shay Tzur
Studies towards Ph.D. Email: shaytzur@gmail.com
Roni Shouval
Studies towards M.Sc. Email: shouval@gmail.com
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