Schiller Jackie - Professor

Jackie Schiller

Main Research Area

The cortex is the largest structure of the brain, and is responsible for complex sensory processing, motor control and all cognitive functions such as thoughts, emotions, learning and memory. The cortex is composed of a complex neuronal network arranged in a highly organized manner. The single member of this network, the neuron, functions as a complex microprocessor. It receives vast input information in the form of thousands of synaptic inputs, and processes this information to form the output function. The incoming synaptic information is received and processed in intricate tree like extensions called dendrites. Dendritic processing is thus a crucial factor determining our learning capabilities, memory and behavior. In my lab we concentrate on two main topics: First, we investigate the fundamental mechanisms of information processing in dendrites of cortical neurons, and their possible contribution to the network function. Second, we study the cellular mechanisms of memory and learning. Sensitive optical and electrophysiological tools are used to visualize and monitor neuronal function in the intact tissue. These include multi-site patch-clamp dendritic and somatic recordings from brain slices combined with fluorescence confocal microscopy as well as intracellular voltage recordings from the intact brain in-vivo. In addition we combine computer simulation studies using biophysically detailed compartmental models in order to gain insights into the complicated function of dendritic physiology.

Journal articles

Click here for a list of available publications in PubMed.
Items 1 – 10
1:   Schiller J, Schiller Y.
NMDA receptor-mediated dendritic spikes and coincident signal amplification.
Curr Opin Neurobiol. 01/06/2001; 11: 343 – 348

2:   Schiller J, Major G, Koester HJ, Schiller Y.
NMDA spikes in basal dendrites of cortical pyramidal neurons.
Nature 16/03/2000; 404: 285 – 289

3:   Edry-Schiller J, Ginsburg S, Rahamimoff R.
A bursting potassium channel in isolated cholinergic synaptosomes of Torpedo electric organ.
J Physiol. 132: 103 – 107

4:   Rahamimoff R, Edry-Schiller J, Ginsburg S.
A long closed state of the synaptosomal bursting potassium channel confers a statistical memory.
J Neurophysiol. 132: 103 – 107

5:   Edry-Schiller J, Rahamimoff R.
Activation and inactivation of the bursting potassium channel from fused Torpedo synaptosomes.
J Physiol. 132: 103 – 107

6:   Rahamimoff R, Edry-Schiller J, Rubin-Fraenkel M, Butkevich A, Ginsburg S.
Oscillations in the activity of a potassium channel at the presynaptic nerve terminal.
J Neurophysiol. 132: 103 – 107

7:   Schiller J, Helmchen F, Sakmann B.
Spatial profile of dendritic calcium transients evoked by action potentials in rat neocortical pyramidal neurones.
J Physiol. 132: 103 – 107

8:   Stuart G, Schiller J, Sakmann B.
Action potential initiation and propagation in rat neocortical pyramidal neurons.
J Physiol. 132: 103 – 107

9:   Schiller J, Schiller Y, Stuart G, Sakmann B.

Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons.
J Physiol. 132: 103 – 107

10:   Schiller J, Schiller Y, Clapham DE.
NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation.
Nat Neurosci. 132: 103 – 107