Reznick Abraham - Associate Professor

רזניק

Alma Mater

1970, B.A. University of Vermont, USA, in Biology and Chemistry
1974, Ph.D. Institute of Molecular Biophysics, Florida State University, USA


Main Research Area

Professor Reznick”s research group is involved in oxidative stress, with ”
“special regard to muscle immobilization and aging, cigarette smoke and ”
“related damage. More recently, the role of transcription factor NF-kB in ”
“muscle breakdown and aging has been the focus of our research.


Research projects

1. Oxidative damage in muscle immobilization and aging.
2. Damage of cigarette smoke to biological systems.
3. Use of thermochemiluminescence(TCL) to detect biological oxidation.
4. The role of transcription factor NF-kB in muscle protein breakdown and in aging and the mechanisms of NF-kB gene activation.


Journal articles

Click here for a list of available publications in PubMed.

Items 1 – 93
1: Zloczower M, Reznick AZ, Zouby RO, Nagler RM
Relationship of flow rate, uric acid, peroxidase, and superoxide dismutase activity levels with complications in diabetic patients: can saliva be used to diagnose diabetes?
Antioxid Redox Signal 01/06/2007; 9: 765 – 773


2: Gochman E, Reznick AZ, Avizohar O, Ben-Amotz A, Levy Y
Exhaustive exercise modifies oxidative stress in smoking subjects
Am J Med Sci 01/06/2007; 333: 346 – 353


3: Reznick AZ, Coleman R, Stein H
Enzymatic activities in limb muscles subjected to external fixation with ring-hybrid frames
Orthopedics 30/04/2007; 30: 277 – 280


4: Weinreb O, Drigues N, Sagi Y, Reznick AZ, Amit T, Youdim MB
The application of proteomics and genomics to the study of age-related neurodegeneration and neuroprotection
Antioxid Redox Signal 09/02/2007; 9: 169 – 179


5: Reznick AZ, Shehadeh N, Shafir Y, Nagler RM
Free radicals related effects and antioxidants in saliva and serum of adolescents with Type I Diabetes mellitus
Arch Oral Biol 01/08/2006; 51: 640 – 648


6: Bar-Shai M, Reznic AZ
Reactive nitrogen species induce nuclear factor-kappaB-mediated protein degradation in skeletal muscle cells
Free Radic Biol Med 15/06/2006; 40: 2112 – 2115


7: Bar-Shai M, Reznick AZ
Peroxynitrite induces and alternative NF-kappaB activation pathway in L8 rat myoblasts
Antioxid Redox Signal 01/03/2006; 8: 639 – 652


8: Bar-Shai M, Carmeli E, Reznick AZ
The role of NF-kappaB in protein breakdown in immobilization, aging, and exercise: from basic processes to promotion of health
Ann N Y Acad Sci 01/12/2005; 1057: 431 – 447


9: Wilson M, Widdicombe JH, Gohil K, Burtis KC, Reznick AZ, Cross CE, Eiserich JP
Are Drosophila a useful model for understanding the toxicity of inhaled oxidative pollutants: a review
Inhal Toxicol 01/12/2005; 17: 765 – 774


10: Bar-Shai M, Carmeli E, Coleman R, Rozen N, Perek S, Fuchs D, Reznick AZ
The effect of hindlimb immobilization on acid phosphatase, metalloproteinases and nuclear factor-kappaB in muscles of young and old rats.
Mech Ageing Dev 01/02/2005; 126: 289 – 97


11: Bar-Shai M, Carmeli E, Coleman R, Rozen N, Perek S, Fuchs D, Reznick AZ
The effect of hindlimb immobilization on acid phosphatase, metalloproteinases and nuclear factor-kappaB in muscles of young and old rats.
Mech Ageing Dev 01/02/2005; 126: 289 – 97


12: Lim Y, Phung AD, Corbacho AM, Aung HH, Maioli E, Reznick AZ, Cross CE, Davis PA, Valacchi G.
Modulation of cutaneous wound healing by ozone: differences between young and aged mice
Toxicol Lett 05/01/2005; 160: 127 – 134


13: Nagler RM, Reznick AZ
Cigarette smoke effects on salivary antioxidants and oral cancer–novel concepts.
Isr Med Assoc J 01/11/2004; 6: 691 – 4


14: Nagler RM, Reznick AZ
Cigarette smoke effects on salivary antioxidants and oral cancer–novel concepts.
Isr Med Assoc J 01/11/2004; 6: 691 – 4


15: Reznick AZ, Hershkovich O, Nagler RM
Saliva–a pivotal player in the pathogenesis of oropharyngeal cancer.
Br J Cancer 01/07/2004; 91: 111 – 8


16: Reznick AZ, Hershkovich O, Nagler RM
Saliva–a pivotal player in the pathogenesis of oropharyngeal cancer.
Br J Cancer 01/07/2004; 91: 111 – 8


17: Voskoboynik A, Rinkevich B, Weiss A, Moiseeva E, Reznick AZ
Macrophage involvement for successful degeneration of apoptotic organs in the colonial urochordate Botryllus schlosseri.
J Exp Biol 01/06/2004; 207: 2409 – 16


18: Bar-Shai M, Carmeli E, Coleman R, Reznick AZ
Mechanisms in muscle atrophy in immobilization and aging.
Ann N Y Acad Sci 01/06/2004; 1019: 475 – 8


19: Bar-Shai M, Carmeli E, Coleman R, Reznick AZ
Mechanisms in muscle atrophy in immobilization and aging.
Ann N Y Acad Sci 01/06/2004; 1019: 475 – 8


20: Voskoboynik A, Rinkevich B, Weiss A, Moiseeva E, Reznick AZ
Macrophage involvement for successful degeneration of apoptotic organs in the colonial urochordate Botryllus schlosseri.
J Exp Biol 01/06/2004; 207: 2409 – 16


21: Hasnis E, Reznick AZ, Pollack S, Klein Y, Nagler RM
Synergistic effect of cigarette smoke and saliva on lymphocytes–the mediatory role of volatile aldehydes and redox active iron and the possible implications for oral cancer.
Int J Biochem Cell Biol 01/05/2004; 36: 826 – 39


22: Hasnis E, Reznick AZ, Pollack S, Klein Y, Nagler RM
Synergistic effect of cigarette smoke and saliva on lymphocytes–the mediatory role of volatile aldehydes and redox active iron and the possible implications for oral cancer.
Int J Biochem Cell Biol 01/05/2004; 36: 826 – 39


23: Lissak A, Wiener-Megnazi Z, Reznick AZ, Shnizer S, Ishai D, Grach B, Lahav-Baratz S, Shiloh H, Koifman M, Dirnfeld M
Oxidative stress indices in seminal plasma, as measured by the thermochemiluminescence assay, correlate with sperm parameters.
Fertil Steril 01/03/2004; 81: 792 – 7


24: Lissak A, Wiener-Megnazi Z, Reznick AZ, Shnizer S, Ishai D, Grach B, Lahav-Baratz S, Shiloh H, Koifman M, Dirnfeld M
Oxidative stress indices in seminal plasma, as measured by the thermochemiluminescence assay, correlate with sperm parameters.
Fertil Steril 01/03/2004; 81: 792 – 7


25: Carmeli E, Moas M, Reznick AZ, Coleman R
Matrix metalloproteinases and skeletal muscle: a brief review.
Muscle Nerve 01/02/2004; 29: 191 – 7


26: Carmeli E, Moas M, Reznick AZ, Coleman R
Matrix metalloproteinases and skeletal muscle: a brief review.
Muscle Nerve 01/02/2004; 29: 191 – 7


27: Ben-Abraham R, Gazit V, Vofsi O, Ben-Shlomo I, Reznick AZ, Katz Y
Beta-phenylpyruvate and glucose uptake in isolated mouse soleus muscle and cultured C2C12 muscle cells.
J Cell Biochem 01/12/2003; 90: 957 – 63


28: Klein I, Nagler RM, Toffler R, van Der Vliet A, Reznick AZ
Effect of cigarette smoke on oral peroxidase activity in human saliva: role of hydrogen cyanide.
Free Radic Biol Med 01/12/2003; 35: 1448 – 52


29: Klein I, Nagler RM, Toffler R, van Der Vliet A, Reznick AZ
Effect of cigarette smoke on oral peroxidase activity in human saliva: role of hydrogen cyanide.
Free Radic Biol Med 01/12/2003; 35: 1448 – 52


30: Ben-Abraham R, Gazit V, Vofsi O, Ben-Shlomo I, Reznick AZ, Katz Y
Beta-phenylpyruvate and glucose uptake in isolated mouse soleus muscle and cultured C2C12 muscle cells.
J Cell Biochem 01/12/2003; 90: 957 – 63


31: Hasnis E, Reznick AZ
Antioxidants and healthy aging.
Isr Med Assoc J 01/05/2003; 5: 368 – 70


32: Reznick AZ, Klein I, Eiserich JP, Cross CE, Nagler RM
Inhibition of oral peroxidase activity by cigarette smoke: in vivo and in vitro studies.
Free Radic Biol Med 01/02/2003; 34: 377 – 84


33: Nagler RM, Salameh F, Reznick AZ, Livshits V, Nahir AM
Salivary gland involvement in rheumatoid arthritis and its relationship to induced oxidative stress.
Rheumatology (Oxford) 01/01/2003; 42: 1234 – 41


34: Reznick AZ, Menashe O, Bar-Shai M, Coleman R, Carmeli E
Expression of matrix metalloproteinases, inhibitor, and acid phosphatase in muscles of immobilized hindlimbs of rats.
Muscle Nerve 01/01/2003; 27: 51 – 9


35: Nagler RM, Salameh F, Reznick AZ, Livshits V, Nahir AM
Salivary gland involvement in rheumatoid arthritis and its relationship to induced oxidative stress.
Rheumatology (Oxford) 01/01/2003; 42: 1234 – 41


36: Nagler RM, Hershkovich O, Lischinsky S, Diamond E, Reznick AZ
Saliva analysis in the clinical setting: revisiting an underused diagnostic tool.
J Investig Med 01/05/2002; 50: 214 – 25


37: Voskoboynik A, Reznick AZ, Rinkevich B
Rejuvenescence and extension of an urochordate life span following a single, acute administration of an anti-oxidant, butylated hydroxytoluene.
Mech Ageing Dev 01/05/2002; 123: 1203 – 10


38: Carmeli E, Ayalon M, Barchad S, Sheklow SL, Reznick AZ
Isokinetic leg strength of institutionalized older adults with mental retardation with and without Down”s syndrome.
J Strength Cond Res 01/05/2002; 16: 316 – 20


39: Carmeli E, Coleman R, Reznick AZ
The biochemistry of aging muscle.
Exp Gerontol 01/04/2002; 37: 477 – 89


40: Nagler RM, Klein I, Zarzhevsky N, Drigues N, Reznick AZ
Characterization of the differentiated antioxidant profile of human saliva.
Free Radic Biol Med 01/02/2002; 32: 268 – 77


41: Nagler RM, Lischinsky S, Diamond E, Klein I, Reznick AZ
New insights into salivary lactate dehydrogenase of human subjects.
J Lab Clin Med 01/05/2001; 137: 363 – 9


42: Zarzhevsky N, Menashe O, Carmeli E, Stein H, Reznick AZ
Capacity for recovery and possible mechanisms in immobilization atrophy of young and old animals.
Ann N Y Acad Sci 01/04/2001; 928: 212 – 25


43: Nguyen H, Finkelstein E, Reznick A, Cross C, van der Vliet A
Cigarette smoke impairs neutrophil respiratory burst activation by aldehyde-induced thiol modifications.
Toxicology 01/03/2001; 160: 207 – 17


44: Zarzhevsky N, Carmeli E, Fuchs D, Coleman R, Stein H, Reznick AZ
Recovery of muscles of old rats after hindlimb immobilisation by external fixation is impaired compared with those of young rats.
Exp Gerontol 01/01/2001; 36: 125 – 40


45: Nagler RM, Reznick AZ, Slavin S, Nagler A
Partial protection of rat parotid glands from irradiation-induced hyposalivation by manganese superoxide dismutase.
Arch Oral Biol 01/09/2000; 45: 741 – 7


46: Nagler R, Lischinsky S, Diamond E, Drigues N, Klein I, Reznick AZ
Effect of cigarette smoke on salivary proteins and enzyme activities.
Arch Biochem Biophys 01/07/2000; 379: 229 – 36


47: Fares FA, Levi F, Reznick AZ, Kraiem Z
Engineering a potential antagonist of human thyrotropin and thyroid-stimulating antibody.
J Biol Chem 01/01/2000; 276: 4543 – 8


48: Reznick AZ, Steinhagen-Thiessen E, Gellersen B, Gershon D
The effect of short- and long-term exercise on aldolase activity in muscles of CW-1 and C57/BL mice of various ages.
Mech Ageing Dev 01/01/2000; 23: 253 – 8


49: Reznick AZ, Gershon D
Age related alterations in purified fructose-1,6-diphosphate aldolase from the nematode Turbatrix aceti.
Mech Ageing Dev 01/01/2000; 6: 345 – 53


50: Shnizer S, Kagan T, Lanir A, Maor I, Reznick AZ
Modifications and oxidation of lipids and proteins in human serum detected by thermochemiluminescence.
Luminescence 01/01/2000; 18: 90 – 6


51: Carmeli E, Reznick AZ, Coleman R, Carmeli V
Muscle strength and mass of lower extremities in relation to functional abilities in elderly adults.
Gerontology 01/01/2000; 46: 249 – 57


52: Zarzhevsky N, Coleman R, Volpin G, Fuchs D, Stein H, Reznick AZ
Muscle recovery after immobilisation by external fixation.
J Bone Joint Surg Br 01/09/1999; 81: 896 – 901


53: Haramaki N, Stewart DB, Aggarwal S, Ikeda H, Reznick AZ, Packer L
Networking antioxidants in the isolated rat heart are selectively depleted by ischemia-reperfusion.
Free Radic Biol Med 01/08/1998; 25: 329 – 39


54: Sen CK, Khanna S, Reznick AZ, Roy S, Packer L
Glutathione regulation of tumor necrosis factor-alpha-induced NF-kappa B activation in skeletal muscle-derived L6 cells.
Biochem Biophys Res Commun 01/08/1997; 237: 645 – 9


55: Fares FA, Gruener N, Carmeli E, Reznick AZ
Growth hormone (GH) retardation of muscle damage due to immobilization in old rats. Possible intervention with a new long-acting recombinant GH.
Ann N Y Acad Sci 01/06/1996; 786: 430 – 43


56: Roisman I, Peretz T, Reznick AZ, Lifshitz I, Bitterman A, Fares F, Toledano H, Barzilay A, Durst AL
[Prognostic factors in breast cancer patients]
Harefuah 01/05/1996; 130: 693 – 9


57: Gross B, Ronen N, Reznick A, Mokady S, Honigman S, Livne E
Biochemical and morphological changes observed in rat muscles following consumption of excessive L-tryptophan and atherogenic diets.
Adv Exp Med Biol 01/01/1996; 398: 575 – 8


58: Lane MA, Reznick AZ, Tilmont EM, Lanir A, Ball SS, Read V, Ingram DK, Cutler RG, Roth GS
Aging and food restriction alter some indices of bone metabolism in male rhesus monkeys (Macaca mulatta).
J Nutr 01/06/1995; 125: 1600 – 10


59: O”Neill CA, Halliwell B, van der Vliet A, Davis PA, Packer L, Tritschler H, Strohman WJ, Rieland T, Cross CE, Reznick AZ
Aldehyde-induced protein modifications in human plasma: protection by glutathione and dihydrolipoic acid.
J Lab Clin Med 01/09/1994; 124: 359 – 70


60: Carmeli E, Reznick AZ
The physiology and biochemistry of skeletal muscle atrophy as a function of age.
Proc Soc Exp Biol Med 01/06/1994; 206: 103 – 13


61: Reznick AZ, Packer L
Oxidative damage to proteins: spectrophotometric method for carbonyl assay.
Methods Enzymol 01/01/1994; 233: 357 – 63


62: Carmeli E, Hochberg Z, Livne E, Lichtenstein I, Kestelboim C, Silbermann M, Reznick AZ
Effect of growth hormone on gastrocnemius muscle of aged rats after immobilization: biochemistry and morphology.
J Appl Physiol 01/10/1993; 75: 1529 – 35


63: Reznick AZ, Witt E, Matsumoto M, Packer L
Vitamin E inhibits protein oxidation in skeletal muscle of resting and exercised rats.
Biochem Biophys Res Commun 01/12/1992; 189: 801 – 6


64: Reznick AZ, Kagan VE, Ramsey R, Tsuchiya M, Khwaja S, Serbinova EA, Packer L
Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation.
Arch Biochem Biophys 01/08/1992; 296: 394 – 401


65: Witt EH, Reznick AZ, Viguie CA, Starke-Reed P, Packer L
Exercise, oxidative damage and effects of antioxidant manipulation.
J Nutr 01/03/1992; 122: 766 – 73


66: Serbinova E, Khwaja S, Reznick AZ, Packer L
Thioctic acid protects against ischemia-reperfusion injury in the isolated perfused Langendorff heart.
Free Radic Res Commun 01/01/1992; 17: 49 – 58


67: Reznick AZ, Witt EH, Silbermann M, Packer L
The threshold of age in exercise and antioxidants action.
EXS 01/01/1992; 62: 423 – 7


68: Cross CE, Reznick AZ, Packer L, Davis PA, Suzuki YJ, Halliwell B
Oxidative damage to human plasma proteins by ozone.
Free Radic Res Commun 01/01/1992; 15: 347 – 52


69: Safadi A, Livne E, Silbermann M, Reznick AZ
Activity of alkaline phosphatase in rat skeletal muscle localized along the sarcolemma and endothelial cell membranes.
J Histochem Cytochem 01/02/1991; 39: 199 – 203


70: Silbermann M, Bar-Shira-Maymon B, Coleman R, Reznick A, Weisman Y, Steinhagen-Thiessen E, von der Mark H, von der Mark K
Long-term physical exercise retards trabecular bone loss in lumbar vertebrae of aging female mice.
Calcif Tissue Int 01/02/1990; 46: 80 – 93


71: Reznick AZ
The cycle of stress–a circular model for the psychobiological response to strain and stress.
Med Hypotheses 01/11/1989; 30: 217 – 22


72: Reznick AZ, Steinhagen-Thiessen E, Silbermann M
Alkaline phosphatase activity in striated mu,scle: the effect of aging and long-term training in female mice.
Arch Gerontol Geriatr 01/07/1989; 9: 59 – 65


73: Lichtig C, Levy J, Gershon D, Reznick AZ
Effect of exercise on the kidney of aging mice.
Isr J Med Sci 01/07/1989; 25: 376 – 81


74: Safadi M, Shapira D, Leichter I, Reznick A, Silbermann M
Ability of different techniques of measuring bone mass to determine vertebral bone loss in aging female rats.
Calcif Tissue Int 01/06/1988; 42: 375 – 82


75: Silbermann M, Weiss A, Reznick AZ, Eilam Y, Szydel N, Gershon D
Age-related trend for osteopenia in femurs of female C57BL/6 mice.
Compr Gerontol [A] 01/02/1987; 1: 45 – 51


76: Steinhagen-Thiessen E, Reznick AZ
Effect of short- and long-term endurance training on creatine phosphokinase activity in skeletal and cardiac muscles of CW-1 and C57BL mice.
Gerontology 01/01/1987; 33: 14 – 8


77: Silbermann M, von der Mark K, van Menxel M, Reznick AZ
Effect of short-term physical stress on DNA and collagen synthesis in the femur of young and old mice.
Gerontology 01/01/1987; 33: 49 – 56


78: Lichtig C, Levy J, Gershon D, Reznick AZ
Effect of aging and exercise on the kidney. Anatomical and morphological studies.
Gerontology 01/01/1987; 33: 40 – 8


79: Coleman R, Silbermann M, Gershon D, Reznick AZ
Giant mitochondria in the myocardium of aging and endurance-trained mice.
Gerontology 01/01/1987; 33: 34 – 9


80: Coleman R, Silbermann M, Gershon D, Reznick AZ
Effects of long-term running stress on the ultrastructure of the aging mouse heart.
Gerontology 01/01/1987; 33: 19 – 33


81: Reznick AZ, Rosenfelder L, Shpund S, Gershon D
Identification of intracellular degradation ,intermediates of aldolase B by antiserum to the denatured enzyme.
Proc Natl Acad Sci U S A 01/09/1985; 82: 6114 – 8


82: Ludatscher RM, Silbermann M, Gershon D, Reznick A
Evidence of Schwann cell degeneration in the aging mouse motor end-plate region.
Exp Gerontol 01/01/1985; 20: 81 – 91


83: Silbermann M, Finkelbrand S, Weiss A, Gershon D, Reznick A
Morphometric analysis of aging skeletal muscle following endurance training.
Muscle Nerve 01/02/1983; 6: 136 – 42


84: Ludatscher R, Silbermann M, Gershon D, Reznick A
The effects of enforced running on the gastrocnemius muscle in aging mice: an ultrastructural study.
Exp Gerontol 01/01/1983; 18: 113 – 23


85: Reznick AZ, Steinhagen-Thiessen E, Gershon D
The effect of exercise on enzyme activities in cardiac muscles of mice of various ages.
Biochem Med 01/12/1982; 28: 347 – 52


86: Lavie L, Reznick AZ, Gershon D
Decreased protein and puromycinyl-peptide degradation in livers of senescent mice.
Biochem J 01/01/1982; 202: 47 – 51


87: Reznick AZ, Lavie L, Gershon HE, Gershon D
Age-associated accumulation of altered FDP aldolase B in mice. Conditions of detection and determination of aldolase half life in young and old animals.
FEBS Lett 01/06/1981; 128: 221 – 4


88: Steinhagen-Thiessen E, Reznick AZ, Hilz H
Positive and negative adaptation of muscle enzymes in aging mice subjected to physical exercise.
Mech Ageing Dev 01/01/1981; 16: 363 – 9


89: Reznick AZ, Gershon D
The effect of age on the protein degradation system in the nematode Turbatrix aceti.
Mech Ageing Dev 01/12/1979; 11: 403 – 15


90: McConnell M, Reznick A, Wright A
Studies on the initial interactions of bacteriophage epsilon15 with its host cell, Salmonella anatum.
Virology 01/04/1979; 94: 10 – 23


91: Goren P, Reznick AZ, Reiss U, Gershon D
Isoelectric properties of nematode aldolase and rat liver superoxide dismutase from young and old animals.
FEBS Lett 01/12/1977; 84: 83 – 6


92: Reznick AZ, Winzler RJ
Physical studies on glycoproteins from ascitic fluid of Ehrlich ascites tumor.
Biochim Biophys Acta 01/04/1976; 428: 441 – 4


93: Reznick AZ, Winzler RJ
Glycoproteins from ascitic fluid of Ehrlich ascites tumor. Isolation and chemical characterization.
Biochim Biophys Acta 01/10/1975; 404: 268 – 73