Perlman Ido - Professor

Perlman Ido

Alma Mater

Department of Physiology, University of Michigan Medical Center

Ann Arbor, Michigan, USA

Main Research Area

Physiology and pathology of the vertebrate retina:

The research in the laboratory deals with visual information processing in the healthy and diseased retina and in the molecular and cellular mechanisms underlying retinal diseases. We study the effects of neuromodulators e.g. nitric oxide and dopamine on light- and dark-adaptation and on the receptive field properties of ganglion cells.

we study the molecular response of the retina to stressful episodes such as light exposure, hyperglycemia, high intraocular pressure, retinal detachement. we invesitgate stress-induced protein expression and the role of these proteins in retinal degeneration.

Research projects

1. The role of retinal neuromodulators, nitric oxide, dopamine and retinoic acid in adjusting retinal function to changing conditions of illumination, and in modulating the modes of visual information processing in the retina.

2. Testing the “bystander effect”: The rle of gap junctions in the spread of degeneration within the photoreceptor layer

3. Stress-induced protein expression in the retina and the role of these proteins in retinal degeneration

Journal articles

Click here for a list of available publications in PubMed.

Items 1 – 10

1: Twig, G. and Perlman, I.
Homogeneity and diversity of color-opponent horizontal cells in the turtle retina: Consequences for potential wavelength discrimination.
Journal of Vision 01/05/2004; 4: 403 – 414

2: Twig, G., Levy, H., Weiner, E. and Perlman, I.
Light adaptation and color opponency of horizontal cells in the turtle retina.
Visual Neuroscience 01/01/2003; 20: 437 – 452

3: Li, Q., Zemel, E., Miller, B. and Perlman, I.
NADPH diaphorase activity in the rat retina during the early stages of experimental diabetes.
Graefeā€™s Archive for Clinical and Experimental Ophthalmology 01/01/2003; 241: 747 – 756

4: Twig, G., Levy, H. and Perlman, I.
Color Opponency in Horizontal Cells of the Vertebrate Retina
Progress in Retinal and Eye Research 01/01/2003; 22: 31 – 68

5: Bornstein, O., Twig, G., Benda, J., Weiler, R. and Perlman, I.
Dynamic changes in the receptive fields of L1-type horizontal cells in the retina of the turtle Mauremys caspica
Visual Neuroscience 01/01/2002; 19: 621 – 632

6: Li, Q., Zemel, E., Miller, B. and Perlman, I.
Early retinal damage in experimental diabetes: electroretinographical and morphological observations
Experimental Eye Research 01/01/2002; 74: 615 – 625

7: Twig G., Levy H. and Perlman I.
Spatial-chromatic interactions in C-type horizontal cells of the turtle (Mauremys caspica) retina
Visual Neuroscience 01/01/2002; 19: 71 – 84

8: Twig G., Levy H. and Perlman I.
Turtle C-type horizontal cells act as push-pull devices
Visual Neuroscience 01/01/2001; 18: 893 – 900

9: Zemel E., Lei B. and Perlman I.
NADPH diaphorase activity in the rabbit retina is modulated by glutamatergic pathways
Journal of Comparative Neurology 01/01/2001; 431: 28 – 38

10: Perlman I., Itzhaki A., Asi H. and Alpern M.
Field sensitivity action spectra of cone photoreceptors in the turtle retina
Journal of Physiology (London) 01/01/1998; 511: 479 – 494