Abassi Zaid - Associate Professor Associate Professor

Zaid Abassi

Main Research Area

Physiology and Endocrinology


Research projects

1. Renal Physiology

2. Vascular Biology

3. Hypertension

4. Endothelin and Nitric Oxide in health and disease

5. Congestive heart Failure- Kidney function and Cardiac hypertrophy

6. Nephrotic Syndrome

7. Effects of increased intraabdominal pressure on kidney function


Journal articles

Click here for a list of available publications in PubMed.

Items 1 –  82

1: Abassi Z, Nakhoul F, Khankin E, Reisner SA, Yigla M
Pulmonary hypertension in chronic dialysis patients with arteriovenous fistula: pathogenesis and therapeutic prospective.
Curr Opin Nephrol Hypertens 01/07/2006; 15: 353 – 60


2: Nakhoul F, Abassi Z, Morgan M, Sussan S, Mirsky N
Inhibition of diabetic nephropathy in rats by an oral antidiabetic material extracted from yeast.
J Am Soc Nephrol 01/04/2006; 17: 0 – 31


3: Azzam ZS, Adir Y, Welch L, Chen J, Winaver J, Factor P, Krivoy N, Hoffman A, Sznajder JI, Abassi Z
ALVEOLAR FLUID REABSORPTION IS INCREASED IN RATS WITH COMPENSATED HEART FAILURE.
Am J Physiol Lung Cell Mol Physiol 01/01/2006;


4: Goldfarb M, Rosenberger C, Abassi Z, Shina A, Zilbersat F, Eckardt KU, Rosen S, Heyman SN
Acute-on-chronic renal failure in the rat: functional compensation and hypoxia tolerance.
Am J Nephrol 01/01/2006; 26: 22 – 33


5: Ovcharenko E, Abassi Z, Rubinstein I, Kaballa A, Hoffman A, Winaver J
Renal effects of human urotensin-II in rats with experimental congestive heart failure.
Nephrol Dial Transplant 01/01/2006; 21: 1205 – 11


6: Winaver J, Abassi Z
Role of neuropeptide Y in the regulation of kidney function.
EXS 01/01/2006; 0: 123 – 32


7: Abassi Z, Bishara B, Yaccob A, Hoffman A
[Vasopressin V2 receptor antagonists: pharmacological properties and clinical implications]
Harefuah 01/12/2005; 144: 875 – 80


8: Barac YD, Zeevi-Levin N, Yaniv G, Reiter I, Milman F, Shilkrut M, Coleman R, Abassi Z, Binah O
The 1,4,5-inositol trisphosphate pathway is a key component in Fas-mediated hypertrophy in neonatal rat ventricular myocytes.
Cardiovasc Res 01/10/2005; 68: 75 – 86


9: Nakhoul F, Ramadan R, Maron M, Abassi Z
Post-splenectomy pseudohyperkalemia in a patient with chronic idiopathic myelofibrosis and thrombocytosis.
Clin Nephrol 01/09/2005; 64: 243 – 6


10: Zeevi-Levin N, Barac YD, Reisner Y, Reiter I, Yaniv G, Meiry G, Abassi Z, Kostin S, Schaper J, Rosen MR, Resnick N, Binah O
Gap junctional remodeling by hypoxia in cultured neonatal rat ventricular myocytes.
Cardiovasc Res 01/04/2005; 66: 64 – 73


11: Winaver J, Ovcharenko E, Rubinstein I, Gurbanov K, Pollesello P, Bishara B, Hoffman A, Abassi Z
Involvement of Rho kinase pathway in the mechanism of renal vasoconstriction and cardiac hypertrophy in rats with experimental heart failure.
Am J Physiol Heart Circ Physiol 01/01/2005; 290: 0 – 14


12: Nakhoul F, Ramadan R, Khankin E, Yaccob A, Kositch Z, Lewin M, Assady S, Abassi Z
Glomerular abundance of nephrin and podocin in experimental nephrotic syndrome: different effects of antiproteinuric therapies.
Am J Physiol Renal Physiol 01/01/2005; 289: 0 – 90


13: Karram T, Abbasi A, Keidar S, Golomb E, Hochberg I, Winaver J, Hoffman A, Abassi Z
Effects of spironolactone and eprosartan on cardiac remodeling and angiotensin-converting enzyme isoforms in rats with experimental heart failure.
Am J Physiol Heart Circ Physiol 01/01/2005; 289: 0 – 8


14: Nakhoul F, Yigla M, Gilman R, Reisner SA, Abassi Z
The pathogenesis of pulmonary hypertension in haemodialysis patients via arterio-venous access.
Nephrol Dial Transplant 01/01/2005; 20: 1686 – 92


15: Keidar S, Gamliel-Lazarovich A, Kaplan M, Pavlotzky E, Hamoud S, Hayek T, Karry R, Abassi Z
Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients.
Circ Res 01/01/2005; 97: 946 – 53


16: Francis B, Winaver J, Karram T, Hoffman A, Abassi Z
Renal and Systemic Effects of Chronic Blockade of ETA or ETB Receptors in Normal Rats and Animals with Experimental Heart Failure.
J Cardiovasc Pharmacol 01/11/2004;


17: Francis BN, Abassi Z, Heyman S, Winaver J, Hoffman A
Differential Regulation of ETA and ETB in the Renal Tissue of Rats with Compensated and Decompensated Heart Failure.
J Cardiovasc Pharmacol 01/11/2004;


18: Hofman C, Francis B, Rosenthal T, Winaver J, Rubinstein I, Abassi Z
Effects of Endothelin-1 on Systemic and Renal Hemodynamics in Hypertensive-Diabetic Rats (CRDH), Diabetic Rats (CDR), and Hypertensive Rats (SHR).
J Cardiovasc Pharmacol 01/11/2004;


19: Abassi Z, Karram T, Ellaham S, Winaver J, Hoffman A
Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance.
Pharmacol Ther 01/06/2004; 102: 223 – 41


20: Nakhoul F, Abassi Z, Plawner M, Khankin E, Ramadan R, Lanir N, Brenner B, Green J
Comparative study of response to treatment with supraphysiologic doses of B-vitamins in hyperhomocysteinemic hemodialysis patients.
Isr Med Assoc J 01/04/2004; 6: 213 – 7


21: Abassi Z, Ramadan R, Schwartz H, Hoffman A
[Therapeutic implications of endothelin antagonists for cardiovascular diseases]
Harefuah 01/01/2004; 143: 47 – 53


22: Abassi ZA, Yahia A, Zeid S, Karram T, Golomb E, Winaver J, Hoffman A
Cardiac and renal effects of omapatrilat, a vasopeptidase inhibitor, in rats with experimental congestive heart failure.
Am J Physiol Heart Circ Physiol 01/01/2004; 288: 0 – 8


23: Fattal I, Abassi Z, Ovcharenko E, Shimada K, Takahashi M, Hoffman A, Winaver J
Effect of dietary sodium intake on the expression of endothelin-converting enzyme in the renal medulla.
Nephron Physiol 01/01/2004; 98: 0 – 96


24: Abassi ZA, Binah O, Youdim MB
Cardiovascular activity of rasagiline, a selective and potent inhibitor of mitochondrial monoamine oxidase B: comparison with selegiline.
Br J Pharmacol 01/01/2004; 143: 371 – 8


25: Abassi ZA, Winaver J, Hoffman A
Large A-V fistula: pathophysiological consequences and therapeutic perspectives.
Curr Vasc Pharmacol 01/10/2003; 1: 347 – 54


26: Yigla M, Nakhoul F, Sabag A, Tov N, Gorevich B, Abassi Z, Reisner SA
Pulmonary hypertension in patients with end-stage renal disease.
Chest 01/05/2003; 123: 1577 – 82


27: Roguin A, Nitecki S, Rubinstein I, Nevo E, Avivi A, Levy NS, Abassi ZA, Sabo E, Lache O, Frank M, Hoffman A, Levy AP
Vascular endothelial growth factor (VEGF) fails to improve blood flow and to promote collateralization in a diabetic mouse ischemic hindlimb model.
Cardiovasc Diabetol 01/01/2003;


28: Roguin A, Avivi A, Nitecki S, Rubinstein I, Levy NS, Abassi ZA, Resnick MB, Lache O, Melamed-Frank M, Joel A, Hoffman A, Nevo E, Levy AP
Restoration of blood flow by using continuous perimuscular infiltration of plasmid DNA encoding subterranean mole rat Spalax ehrenbergi VEGF.
Proc Natl Acad Sci U S A 01/01/2003; 100: 4644 – 8


29: Abassi Z, Francis B, Wessale J, Ovcharenko E, Winaver J, Hoffman A
Effects of endothelin receptors ET(A) and ET(B) blockade on renal haemodynamics in normal rats and in rats with experimental congestive heart failure.
Clin Sci (Lond) 01/08/2002; 103: 245 – 248


30: Karram T, Hoffman A, Abbasi A, Abassi Z
[Aldosterone–classic and non classic effects]
Harefuah 01/06/2002; 141: 544 – 51


31: Gealekman O, Abassi Z, Rubinstein I, Winaver J, Binah O
Role of myocardial inducible nitric oxide synthase in contractile dysfunction and beta-adrenergic hyporesponsiveness in rats with experimental volume-overload heart failure.
Circulation 01/01/2002; 105: 236 – 43


32: Bialik GM, Abassi ZA, Hammel I, Winaver J, Lewinson D
Evaluation of atrial natriuretic peptide and brain natriuretic peptide in atrial granules of rats with experimental congestive heart failure.
J Histochem Cytochem 01/10/2001; 49: 1293 – 300


33: Abassi ZA, Ellahham S, Winaver J, Hoffman A
The intrarenal endothelin system and hypertension.
News Physiol Sci 01/08/2001; 16: 152 – 6


34: Abassi ZA, Brodsky S, Karram T, Dobkin I, Winaver J, Hoffman A
Temporal changes in natriuretic and antinatriuretic systems after closure of a large arteriovenous fistula.
Cardiovasc Res 01/08/2001; 51: 567 – 76


35: Goldfarb M, Abassi Z, Rosen S, Shina A, Brezis M, Heyman SN
Compensated heart failure predisposes to outer medullary tubular injury: studies in rats.
Kidney Int 01/08/2001; 60: 607 – 13


36: Abassi Z, Brodsky S, Gealekman O, Rubinstein I, Hoffman A, Winaver J
Intrarenal expression and distribution of cyclooxygenase isoforms in rats with experimental heart failure.
Am J Physiol Renal Physiol 01/01/2001; 280: 0 – 53


37: Brodsky S, Abassi Z, Wessale J, Ramadan R, Winaver J, Hoffman A
Effects of A-192621.1, a specific endothelin-B antagonist, on intrarenal hemodynamic responses to endothelin-1.
J Cardiovasc Pharmacol 01/11/2000; 36: 0 – 3


38: Ellahham SH, Charlon V, Abassi Z, Calis KA, Choucair WK
Bosentan and the endothelin system in congestive heart failure.
Clin Cardiol 01/11/2000; 23: 803 – 7


39: Green J, Assady S, Nakhoul F, Bick T, Jakobi P, Abassi Z
Differential effects of sera from normotensive and hypertensive pregnant women on Ca(2+) metabolism in normal vasular smooth muscle cells.
J Am Soc Nephrol 01/07/2000; 11: 1188 – 98


40: Hoffman A, Abassi ZA, Brodsky S, Ramadan R, Winaver J
Mechanisms of big endothelin-1-induced diuresis and natriuresis : role of ET(B) receptors.
Hypertension 01/03/2000; 35: 732 – 9


41: Abassi Z, Hoffman A, Nakhoul F
[Aquaporins (water channels): physiology and pathophysiology]
Harefuah 01/03/2000; 138: 488 – 94


42: Karram T, Hoffman A, Bishara B, Brodsky S, Golomb E, Winaver J, Abassi Z
Induction of cardiac hypertrophy by a controlled reproducible sutureless aortocaval shunt in the mouse.
J Invest Surg 01/01/2000; 18: 325 – 34


43: Yigla M, Abassi Z, Reisner SA, Nakhoul F
Pulmonary hypertension in hemodialysis patients: an unrecognized threat.
Semin Dial 01/01/2000; 19: 353 – 7


44: Brodsky S, Gurbanov K, Abassi Z, Hoffman A, Ruffolo RR, Feuerstein GZ, Winaver J
Effects of eprosartan on renal function and cardiac hypertrophy in rats with experimental heart failure.
Hypertension 01/10/1998; 32: 746 – 52


45: Abassi ZA, Hoffman A, Better OS
Acute renal failure complicating muscle crush injury.
Semin Nephrol 01/09/1998; 18: 558 – 65


46: Abassi Z, Gurbanov K, Rubinstein I, Better OS, Hoffman A, Winaver J
Regulation of intrarenal blood flow in experimental heart failure: role of endothelin and nitric oxide.
Am J Physiol 01/04/1998; 274: 0 – 74


47: Rubinstein I, Abassi Z, Coleman R, Milman F, Winaver J, Better OS
Involvement of nitric oxide system in experimental muscle crush injury.
J Clin Invest 01/03/1998; 101: 1325 – 33


48: Abassi Z, Winaver J, Rubinstein I, Shimada K, Takahashi M, Tanzawa K, Hoffman A
Renal endothelin-converting enzyme in rats with congestive heart failure.
J Cardiovasc Pharmacol 01/01/1998; 31: 0 – 4


49: Abassi ZA, Gurbanov K, Mulroney SE, Potlog C, Opgenorth TJ, Hoffman A, Haramati A, Winaver J
Impaired nitric oxide-mediated renal vasodilation in rats with experimental heart failure: role of angiotensin II.
Circulation 01/11/1997; 96: 3655 – 64


50: Abassi Z, Kotob S, Pieruzzi F, Abouassali M, Keiser HR, Fratantoni JC, Alayash AI
Effects of polymerization on the hypertensive action of diaspirin cross-linked hemoglobin in rats.
J Lab Clin Med 01/06/1997; 129: 603 – 10


51: Dekel B, Nakhoul F, Abassi Z, Aviv R, Winaver J, Szylman P
Complete adaptation to chronic potassium loading after adrenalectomy: possible humoral mechanisms.
J Lab Clin Med 01/04/1997; 129: 453 – 61


52: Gurbanov K, Rubinstein I, Hoffman A, Abassi Z, Better OS, Winaver J
Differential regulation of renal regional blood flow by endothelin-1.
Am J Physiol 01/12/1996; 271: 0 – 72


53: Gurbanov K, Rubinstein I, Hoffman A, Abassi Z, Better OS, Winaver J
Bosentan improves renal regional blood flow in rats with experimental congestive heart failure.
Eur J Pharmacol 01/08/1996; 310: 193 – 6


54: Abassi ZA, Pieruzzi F, Nakhoul F, Keiser HR
Effects of cyclosporin A on the synthesis, excretion, and metabolism of endothelin in the rat.
Hypertension 01/05/1996; 27: 1140 – 8


55: Nakhoul F, Green J, Abassi ZA, Carter A
Tumor lysis syndrome induced by fludarabine monophosphate: a case report.
Eur J Haematol 01/04/1996; 56: 254 – 5


56: Pieruzzi F, Abassi ZA, Keiser HR
Expression of renin-angiotensin system components in the heart, kidneys, and lungs of rats with experimental heart failure.
Circulation 01/11/1995; 92: 3105 – 12


57: Wolfovitz E, Pacak K, Abassi Z, Kopin IJ, Goldstein DS
Effects of hypercortisolemia or hyperinsulinemia on neurochemical indices of catecholamine release and synthesis in conscious rats.
J Auton Nerv Syst 01/08/1995; 54: 104 – 12


58: Abassi ZA, Kotob S, Golomb E, Pieruzzi F, Keiser HR
Pulmonary and renal neutral endopeptidase EC 3.4.24.11 in rats with experimental heart failure.
Hypertension 01/06/1995; 25: 1178 – 84


59: Klein H, Abassi Z, Keiser HR
Effects of angiotensin II and phenylephrine on urinary endothelin in normal female volunteers.
Metabolism 01/01/1995; 44: 115 – 8


60: Hoffman A, Grossman E, Abassi ZA, Keiser HR
Renal endothelin and hypertension.
Nature 01/11/1994;


61: Golomb E, Abassi ZA, Cuda G, Stylianou M, Panchal VR, Trachewsky D, Keiser HR
Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats.
Am J Physiol 01/10/1994; 267: 0 – 506


62: Abassi ZA, Golomb E, Agbaria R, Roller PP, Tate J, Keiser HR
Hydrolysis of iodine labelled urodilatin and ANP by recombinant neutral endopeptidase EC. 3.4.24.11.
Br J Pharmacol 01/09/1994; 113: 204 – 8


63: Abassi ZA, Kelly G, Golomb E, Klein H, Keiser HR
Losartan improves the natriuretic response to ANF in rats with high-output heart failure.
J Pharmacol Exp Ther 01/01/1994; 268: 224 – 30


64: Abassi ZA, Klein H, Golomb E, Keiser HR
Urinary endothelin: a possible biological marker of renal damage.
Am J Hypertens 01/12/1993; 6: 1046 – 54


65: Golomb E, Friedman E, Abassi ZA, Trachewsky D, Keiser HR
Rare renal transcription of the atrial natriuretic factor gene in rats. Demonstration by polymerase chain reaction.
Am J Hypertens 01/10/1993; 6: 867 – 72


66: Abassi ZA, Golomb E, Bridenbaugh R, Keiser HR
Metabolism of endothelin-1 and big endothelin-1 by recombinant neutral endopeptidase EC.3.4.24.11.
Br J Pharmacol 01/08/1993; 109: 1024 – 8


67: Abassi ZA, Klein H, Cox J, Keiser HR
Bradykinin does not modulate the natriuretic response to atrial natriuretic factor in rats with aortocaval fistula.
Hypertension 01/06/1993; 21: 966 – 70


68: Abassi ZA, Klein H, Golomb E, Keiser HR
Regulation of the urinary excretion of endothelin in the rat.
Am J Hypertens 01/06/1993; 6: 453 – 7


69: Abassi ZA, Tate J, Hunsberger S, Klein H, Trachewsky D, Keiser HR
Pharmacokinetics of ANF and urodilatin during cANF receptor blockade and neutral endopeptidase inhibition.
Am J Physiol 01/11/1992; 263: 0 – 6


70: Grossman E, Hoffman A, Armando I, Abassi Z, Kopin IJ, Goldstein DS
Sympathoadrenal contribution to plasma dopa (3,4-dihydroxyphenylalanine) in rats.
Clin Sci (Lond) 01/07/1992; 83: 65 – 74


71: Abassi ZA, Tate JE, Golomb E, Keiser HR
Role of neutral endopeptidase in the metabolism of endothelin.
Hypertension 01/07/1992; 20: 89 – 95


72: Abassi Z, Golomb E, Keiser HR
Neutral endopeptidase inhibition increases the urinary excretion and plasma levels of endothelin.
Metabolism 01/07/1992; 41: 683 – 5


73: Abassi Z, Shuranyi E, Better OS, Winaver J
Effect of atrial natriuretic factor on renal cGMP production in rats with adriamycin-induced nephrotic syndrome.
J Am Soc Nephrol 01/04/1992; 2: 1538 – 44


74: Abassi ZA, Powell JR, Golomb E, Keiser HR
Renal and systemic effects of urodilatin in rats with high-output heart failure.
Am J Physiol 01/04/1992; 262: 0 – 21


75: Har-Shai Y, Silbermann M, Reis ND, Zinman C, Rubinstein I, Abassi Z, Better OS
Muscle microcirculatory impairment following acute compartment syndrome in the dog.
Plast Reconstr Surg 01/02/1992; 89: 283 – 9


76: Abassi Z, Burnett JC, Grushka E, Hoffman A, Haramati A, Winaver J
Atrial natriuretic peptide and renal cGMP in rats with experimental heart failure.
Am J Physiol 01/10/1991; 261: 0 – 64


77: Abassi Z, Winaver J, Hoffman A, Better OS
[Endothelin: a new vasoconstrictor of endothelial origin]
Harefuah 01/04/1991; 120: 388 – 92


78: Better OS, Zinman C, Reis DN, Har-Shai Y, Rubinstein I, Abassi Z
Hypertonic mannitol ameliorates intracompartmental tamponade in model compartment syndrome in the dog.
Nephron 01/01/1991; 58: 344 – 6


79: Abassi Z, Haramati A, Hoffman A, Burnett JC, Winaver J
Effect of converting-enzyme inhibition on renal response to ANF in rats with experimental heart failure.
Am J Physiol 01/07/1990; 259: 0 – 9


80: Better OS, Abassi Z, Rubinstein I, Marom S, Winaver Y, Silberman M
The mechanism of muscle injury in the crush syndrome: ischemic versus pressure-stretch myopathy.
Miner Electrolyte Metab 01/01/1990; 16: 181 – 4


81: Abassi Z, Winaver J, Gery R, Better OS
[Pathophysiology of atrial peptides actions]
Harefuah 01/01/1990; 118: 31 – 6


82: Abassi Z, Winaver J
[Atrial natriuretic factor (ANF)–physiological aspects]
Harefuah 01/11/1988; 115: 296 – 300